UNITY Biotechnology was the first senolytic startup out of the gate, and the failure of its Phase II trial in osteoarthritis was a crushing disappointment. A careful look back at the underlying science and three new scientific papers give us a good idea why and suggest ways to move forward.
One way senescent cells accumulate is when one senescent cell turns a neighboring cell senescent through SASP secretion. SRF scientists have discovered that these secondary senescent cells are resistant to the classic senolytic drugs. However, they have identified a new senolytic strategy that kills these senescent cells.
Week One of our 2022 End of Year Campaign features ApoptoSENS (Removing Dysfunctional Cells) – with a disease focus on Challenging Alzheimer’s. Also featuring videos from Life Noggin, AMA with Dr. Amit Sharma and Michael Rae.
A supporter asks if SENS rejuvenation biotechnologies will benefit patients with progerias — so-called “premature aging” diseases.
For our SENSible Question series, a supporter asks if there are any common lab tests available that could be used as a readout of a person’s burden of inflammatory signals from senescent cells. The answer is ‘no,’ unfortunately, but we review a number of hard-to-access or research-only tests that might be able to tell us something with a bit more work.
Research Info When normal cells lose their ability to replicate, they become senescent cells. Over time, senescent cells accumulate in aging tissues, spewing off a cocktail of inflammatory and growth factors, as well as enzymes that break down surrounding tissue and cause inflammation. This phenomenon is known as the “senescence-associated secretory phenotype” (SASP). Senescent cells – and …
SENS Research Foundation Research Center Forever Healthy Foundation Fellowship in Rejuvenation Biotechnology Fellow: Tesfahun Admasu When cells age, they lose their proliferative capacity and stop dividing in a phenomenon called senescence. Cellular senescence decreases the regenerative capacity of cells and tissues. Throughout the aging process, senescent cells accumulate and secrete a characteristic set of proteins, called …
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© 2024 SENS Research Foundation – ALL RIGHTS RESERVED
