The Problem Early studies show that destroying senescent, or old and dysfunctional, cells can delay or even reverse diseases of aging and extend lifespan. The primary strategy for turning this into a therapy has been “senolytic” drugs that target signaling pathways that senescent cells need for survival. The Goal An alternative approach, targeting senescent cells …
The Problem Senescent, or old, cells drive diseases of aging in tissues far removed from where the damaged cells are located. It is assumed that these effects result from factors that senescent cells release (the “SASP”) being carried by the blood, but this hasn’t been proven in studies. If senescent cells don’t raise the level …
The Problem IPF is linked to the accumulation of senescent, or old, cells in the lung, creating scar tissue (fibrosis) which progressively stiffens them. This disables the patient, eventually suffocating them within 2-4 years. IPF creates a high burden of senescent cells in the lungs, and removing senescent cells powerfully impacts the disease. Previous drug …
The Problem The immune system has an ability to patrol for and destroy senescent, or aged cells, a function which deteriorates over time, permitting senescent cells to accumulate and drive age-related disease. The negative impacts from senescence may actually result from a joint attack by both senescent cells and activated macrophages – a type of …
The Problem The immune system can patrol for and destroy senescent, or aged cells. Senescent cells are drivers of age-related disease and removing them helps remediate aged tissues. It was recently discovered that these cells have an unusually high metabolism. The Goal Reduce the metabolism in the senescent cells to see if doing so …
The Problem The immune system, including natural killer cells (NK cells), has an ability to patrol for and destroy senescent, or aged cells. However, this protective function deteriorates over time, permitting senescent cells to accumulate in our tissues and drive age-related disease. Drugs used to destroy senescent cells – senolytics – use a brute-force method …
The Problem Aging creates an accumulation of mutations in the DNA of our mitochondria, the organelles that create our energy supply on a molecular level. This impacts and impairs their ability to function correctly and creates a myriad of energy issues as we age. Testing potential therapies for use in humans requires a robust testing …
The Problem Aging creates an accumulation of mutations in the DNA of our mitochondria, the organelles that create our energy supply on a molecular level. This impacts and impairs their ability to function correctly and creates a myriad of energy issues as we age. The Goal The team is creating a drive to implant new …
The Problem Aging creates an accumulation of mutations in the DNA of our mitochondria, the organelles that create our energy supply on a molecular level. This impacts and impairs their ability to function correctly and creates a myriad of energy issues as we age. The most prevalent and dangerous types of mutations are the large …
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