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Tools to fight the cataract epidemic: A review of experimental animal models that mimic age related nuclear cataract.
Lim JC, Umapathy A, Donaldson PJ
Abstract:
.....This review will provide an overview of the cataract specific changes previously reported in human cataract lenses, before focussing on the specific changes that occur in age related nuclear (ARN) cataract, the most common form of cataract in humans. This will be followed by a discussion of a range of existing animal cataract models and their respective suitability for mimicking the processes associated with the development of ARN cataract, and therefore their utility as models to test anti-cataract therapies for future use in humans.
