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The systems biology of mitochondrial fission and fusion and implications for disease and aging.
Chauhan A, Vera J, Wolkenhauer O
Abstract:
.....We discuss how systems biology approaches can be used to investigate the mechanisms controlling the fission-fusion dynamics under two categories: dissecting the design of its molecular regulatory motifs, and understanding complex mitochondrial responses through their population level interactions. This will help us to understand how different regulatory mechanisms regulate the ATP and mutation (mtDNA) landscape of mitochondria to a variety of environmental stimuli in order to maintain their function during aging.
PMID: 24122214
SENS Approach:
