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The effects of aging on semen parameters and sperm DNA fragmentation
JBRA Assist Reprod. 2020 Jan 30;24(1):82-86. doi: 10.5935/1518-0557.20190058.
Víctor Pino 1, Antonia Sanz 1, Nicolás Valdés 2, Javier Crosby 3, Antonio Mackenna 4
Abstract:
Introduction: This study aimed to look into possible correlations between male age and different sperm parameters derived from semen analysis and sperm deoxyribonucleic acid (DNA) fragmentation.
Methods: This retrospective descriptive study included 2681 male patients who underwent semen analysis at Clínica Las Condes (CLC), Santiago, Chile, between January 2014 and May 2017; correlations between age and sperm parameters were analyzed.
Results: Males above the age of 50 were significantly more likely to present anomalies in semen volume, sperm concentration, and sperm DNA fragmentation; males aged 41+ years were more likely to have lower sperm concentration levels; males aged 31+ years were more likely to have decreased sperm motility; when concentration was constant, more volume and motility anomalies were seen as age increased; when volume was kept constant, more motility and concentration anomalies were seen as age increased; and when motility was constant, normal semen volumes decreased as age increased.
Conclusion: Our study showed that male age significantly affects sperm parameters that might have an impact on male fertility.
Methods: This retrospective descriptive study included 2681 male patients who underwent semen analysis at Clínica Las Condes (CLC), Santiago, Chile, between January 2014 and May 2017; correlations between age and sperm parameters were analyzed.
Results: Males above the age of 50 were significantly more likely to present anomalies in semen volume, sperm concentration, and sperm DNA fragmentation; males aged 41+ years were more likely to have lower sperm concentration levels; males aged 31+ years were more likely to have decreased sperm motility; when concentration was constant, more volume and motility anomalies were seen as age increased; when volume was kept constant, more motility and concentration anomalies were seen as age increased; and when motility was constant, normal semen volumes decreased as age increased.
Conclusion: Our study showed that male age significantly affects sperm parameters that might have an impact on male fertility.
PMID: 31692316
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993171/
Tags: DNA fragmentation, humans, males, reproduction, sperm