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The Effect of Age on Thymic Function.
Palmer DB
Abstract:
.....Thymic involution is one of the most dramatic and ubiquitous changes seen in the aging immune system, but the mechanisms which underlying this process are poorly understood. However, a picture is emerging, implicating the involvement of both extrinsic and intrinsic factors. In this review we assess the role of the thymic microenvironment as a potential target that regulates thymic involution, question whether thymocyte development in the aged thymus is functionally impaired, and explore the kinetics of thymic involution.
PMID: 24109481
Free Full-Text: http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24109481/
