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The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degeneration.
Dietzel M, Pauleikhoff D, Arning A, Heimes B, Lommatzsch A, Stoll M, Hense HW
Abstract:
.....We aimed to assess the association of drusen as phenotypic characteristics of early AMD and their progression with polymorphisms in the CFH, ABCA1, and ARMS2 genes. In the Münster Aging and Retina Study (MARS), drusen were detected in 406 patients with early AMD and 170 healthy controls according to the International Classification using fundus photographs, with a follow-up examination after 2.6 years (median). Six drusen features were assessed: drusen number (
PMID: 24970616
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