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Telomerase at the intersection of cancer and aging.
Trends Genet. 2013 Jul 19. pii: S0168-9525(13)00108-X. doi: 10.1016/j.tig.2013.06.007
Bernardes de Jesus B, Blasco MA
Abstract:
.....Here, we revisit the connection between telomerase and cancer and aging in light of recent findings supporting a role for telomerase not only in telomere elongation, but also in metabolic fitness and Wnt activation. Understanding the physiological impact of telomerase regulation is fundamental given the therapeutic strategies that are being developed that involve telomerase modulation.
PMID: 23876621
Tags: review