SENS PubMed Publication Search
Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration
Jae-Byoung Chae # 1, Hyoik Jang # 1, Chanok Son 1, Chul-Woo Park 1, Huyeon Choi 2, Seongeon Jin 2, Ho-Yeon Lee 3 4, Hyungwoo Lee 5, Ja-Hyoung Ryu 2, Namshin Kim 3 4, Chaekyu Kim 6, Hyewon Chung 7 8
Abstract:
...Here, we report that the elimination of senescent cells is a potential novel therapeutic approach for the treatment of all types of AMD. We identified senescent retinal pigment epithelium (RPE) cells in animal models of AMD and determined their contributions to retinal degeneration. We further confirmed that the clearance of senescent RPE cells with the MDM2-p53 inhibitor Nutlin-3a ameliorated retinal degeneration. These findings provide new insights into the use of senescent cells as a therapeutic target for the treatment of AMD.
PMID: 34601706
SENS Approach:
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