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T1-weighted MRI-driven Brain Age Estimation in Alzheimer's Disease and Parkinson's Disease
Aging Dis. 2020 May 9;11(3):618-628. doi: 10.14336/AD.2019.0617.
Iman Beheshti 1, Shiwangi Mishra 2, Daichi Sone 1, Pritee Khanna 2, Hiroshi Matsuda 1
Abstract:
...Here, we computed and compared brain age in Alzheimer's disease (AD) and Parkinson's disease (PD) patients using an advanced machine learning procedure involving T1-weighted MRI scans and gray matter (GM) and white matter (WM) models. Brain age estimation frameworks were built using 839 healthy individuals and then the brain estimated age difference (Brain-EAD: chronological age subtracted from brain estimated age) was assessed in a large sample of PD patients (n = 160) and AD patients (n = 129), respectively. The mean Brain-EADs for GM were +9.29 ± 6.43 years for AD patients versus +1.50 ± 6.03 years for PD patients. For WM, the mean Brain-EADs were +8.85 ± 6.62 years for AD patients versus +2.47 ± 5.85 years for PD patients. In addition, PD patients showed a significantly higher WM Brain-EAD than GM Brain-EAD. In a direct comparison between PD and AD patients, we observed significantly higher Brain-EAD values in AD patients for both GM and WM. A comparison of the Brain-EAD between PD and AD patients revealed that AD patients may have a significantly "older-appearing" brain than PD patients.
PMID: 32489706
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220281/
Tags: Alzheimer’s, brain atrophy, Gray matter, humans, MRI, parkinson's, white matter