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Specific death of ALT cells through TSPYL5 depletion
Eloïse Claude 1, Harikleia Episkopou 1, Anabelle Decottignies 1
Abstract:
Some tumors acquire replicative immortality by activating an ALTernative telomerase-independent telomere maintenance mechanism. ALT offers interesting therapeutic perspectives but lacks any known specific targets. We discovered a crucial role for TSPYL5 (Testis-Specific Y-encoded-Like Protein 5) in keeping ALT cell viability by protecting POT1 (Protection Of Telomeres 1) from proteasomal degradation.
PMID: 31692925
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816424/
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