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Species-specific lifespans: Can it be a lottery based on the mode of mitochondrial DNA replication?
Khaidakov M
Abstract:
Accumulating evidence suggests that the aging process is, in part, driven by accumulation of large deletions in mitochondrial DNA (mtDNA). Here, I present a hypothesis that significant variations in lifespans can be explained by species-specific mtDNA sequence features that cause a shift in the mode of mtDNA replication and thus preclude the formation of large deletions.
PMID: 26930297
SENS Approach:
