SENS PubMed Publication Search
Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease
Brain Commun. 2021 Jul 2;3(3):fcab147. doi: 10.1093/braincomms/fcab147.
Dimitrios I Sideris 1 2, John S H Danial 1, Derya Emin 1, Francesco S Ruggeri 1 3, Zengjie Xia 1, Yu P Zhang 1, Evgeniia Lobanova 1, Helen Dakin 1, Suman De 1, Alyssa Miller 1, Jason C Sang 1, Tuomas P J Knowles 1 4, Michele Vendruscolo 1, Graham Fraser 2, Damian Crowther 2, David Klenerman 1 5
Abstract:
...We have used a variety of biophysical methods to characterize the aggregates present in human Alzheimer's disease brains at Braak stage III. We find soluble amyloid beta-containing aggregates in all regions of the brain up to 200 nm in length, capable of causing an inflammatory response. Rather than aggregates spreading through the brain as disease progresses, it appears that aggregation occurs all over the brain and that different brain regions are at earlier or later stages of the same process, with the later stages causing increased inflammation.
PMID: 34396107
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361392/