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Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments.
Ke CJ, Su TY, Chen HL, Liu HL, Chiang WL, Chu PC, Xia Y, Sung HW
Abstract:
Prepared to self-destruct: when poly(D, L-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO(3) entered the endocytic organelles of a live cell, the NaHCO(3) in the aqueous core reacted with protons that infiltrated from the compartment to generate CO(2) gas. The evolution of CO(2) bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin.
PMID: 21751316
SENS Approach:
