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Small molecule compounds that induce cellular senescence.
Aging Cell. 2016 Sep 14. doi: 10.1111/acel.12518
Petrova NV, Velichko AK, Razin SV, Kantidze OL
Abstract:
To date, dozens of stress-induced cellular senescence phenotypes have been reported. These cellular senescence states may differ substantially from each other, as well as from replicative senescence through the presence of specific senescence features. Here, we attempted to catalog virtually all of the cellular senescence-like states that can be induced by low molecular weight compounds. We summarized biological markers, molecular pathways involved in senescence establishment, and specific traits of cellular senescence states induced by more than fifty small molecule compounds.
PMID: 27628712
Free Full-Text: http://onlinelibrary.wiley.com/doi/10.1111/acel.12518/full
Tags: cellular senescence, methods, review