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Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia
Davis A Englund 1, Alyssa M Jolliffe 1, Gabriel J Hanson 1, Zaira Aversa 2, Xu Zhang 1, Xinyi Jiang 2, Thomas A White 1, Lei Zhang 3, David G Monroe 1, Paul D Robbins 3, Laura J Niedernhofer 3, Theodore M Kamenecka 4, Sundeep Khosla 5, Nathan K LeBrasseur 2
Abstract:
...Herein, we show that treatment with the IKK/NF-κB inhibitor SR12343 during a course of chemotherapy reduces markers of cellular senescence and the SASP in liver, skeletal muscle, and circulation and, correspondingly, attenuates features of skeletal muscle pathology. Lastly, we demonstrate SR12343 mitigates chemotherapy-induced reductions in body weight, lean mass, fat mass, and muscle strength. These findings support senescent cells as a promising druggable target to counteract the SASP and skeletal muscle wasting in the context of chemotherapy.
PMID: 38051584
Free Full-Text: https://insight.jci.org/articles/view/169512/pdf
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