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Senescent dermal fibroblasts decrease stemness in basal keratinocytes in a bioengineered model of human full thickness skin
Evon Low 1, Lucy A Smith 2, Satomi Miwa 1, Edward Fielder 1, Stefan Przyborski 3, Thomas von Zglinicki 4
Abstract:
(The following are selected excerpts from the full-text manuscript): In conclusion, although senescent fibroblasts induced a SASP similar to observations in aged skin (Low et al., 2021) and in collagen-based 3D skin models (Weinmüllner et al., 2020), they did not induce keratinocyte senescence. However, they did cause a reduction of the stemness marker p63 specifically in the basal layer, which might be the cause of the observed epidermal thinning. Matrix composition may be a major modifier of the effect of senescent fibroblasts onto the epidermal equivalent.
PMID: 39047968
Free Full-Text: https://www.jidonline.org/article/S0022-202X(24)01916-X/fulltext
SENS Approach:
