SENS PubMed Publication Search
Sci Rep. 2020 Jul 20;10(1):12003. doi: 10.1038/s41598-020-68681-0.
Abstract:
Numerous theoretical studies have been conducted on the effects of high-voltage electric fields on proteins, but few have produced experimental evidence. To acquire experimental data for the amyloid disassemble theory, we exposed transthyretin aggregates to 1,000 ns 1.26 MV/cm pulsed electric fields (PEFs) to promote transthyretin degradation. The process produced no changes in pH, and the resulting temperature increases were < 1 °C. We conclude that the physical effects of PEFs, rather than thermal or chemical effects, facilitate aggregate degradation.
PMID: 32686729
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371718/
