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Role of dendritic cells in innate and adaptive immune response in human aging.
Gupta S
Abstract:
.....[Dendritic cells, or] DCs in aging appear to be functionally impaired with regard to response to uptake of antigens, phagocytosis of apoptotic cells, migration, priming of CD4+ and CD8+ T cells, and production of IFN-I and IFN-III. In this review I have discussed various mechanisms, which may be responsible for impaired functions of DCs.
