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Quinoline-Based Fluorescent Probe for Ratiometric Detection of Lysosomal pH.
Li G, Zhu D, Xue L, Jiang H
Abstract:
A new pH-responsive fluorescent probe has been reported based on protonation-activable resonance charge transfer. In aqueous solution, probe PQ-Lyso exhibits ratiometric detection of pH changes with a large hypsochromic shift of 76 nm and remarkable changes in the fluorescence intensity ratio (R = F494 nm/F570 nm, R/R0 = 105). Furthermore, PQ-Lyso, which is localized to lysosomes in living cells, can calibrate lysosomal pH using fluorescence ratiometry.
PMID: 24040756
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