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Pseudoexfoliation syndrome: The critical role of the extracellular matrix in pathogenesis and treatment
Stylianos Mastronikolis 1 2, Marina Pagkalou 3, Giorgos Baroutas 4, Konstantina Kyriakopoulou 4, Οlga E Makri 1, Constantinos D Georgakopoulos 1
Abstract:
...In addition, PEXS initiation is tightly connected with the dysregulation of extracellular matrix (ECM) homeostasis since aberrant expression of ECM molecules is linked to both the accumulation and low degradation of pseudoexfoliation material. This article aims at uncovering the crucial role of various ECM effectors such as lysyl oxidase-like proteins, matrix metalloproteinases, and TGF-β1, as well as the biochemical pathways involved in the development and the progression of the PEXS.
