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Protein carbonylation: Proteomics, specificity and relevance to aging.
Mass Spectrom Rev. 2014 Jan;33(1):21-48. doi: 10.1002/mas.21375
Cabiscol E, Tamarit J, Ros J
Abstract:
Detection and quantification of protein carbonyls present in biological samples has become a popular, albeit indirect, method to determine the existence of oxidative stress. .....This review discusses these methodologies and proteomic strategies and then focuses on the relationship between protein carbonylation and aging and the parameters that may explain the increased sensitivity of certain proteins to protein carbonylation.
PMID: 24114980
Tags: protein carbonylation, review