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Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres
Timothy P Lippert 1 2, Paulina Marzec 1, Aurora I Idilli 1, Grzegorz Sarek 1, Aleksandra Vancevska 1, Mark Bower 3, Paul J Farrell 4, Päivi M Ojala 4 5, Niklas Feldhahn # 2, Simon J Boulton # 6
Abstract:
...Here, we demonstrate that infection with Kaposi's sarcoma herpesvirus (KSHV) induces sustained acquisition of ALT-like features in previously non-ALT cell lines. KSHV-infected cells acquire hallmarks of ALT activity that are also observed in KSHV-associated tumour biopsies. Down-regulating BIR impairs KSHV latency, suggesting that KSHV co-opts ALT for viral functionality. This study uncovers KSHV infection as a means to study telomere maintenance by ALT and reveals features of ALT in KSHV-associated tumours.
PMID: 33479235
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820467/
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