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Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin
Mari Saif # 1, Wilhelmus J Kwanten # 2 3, Jessica A Carr # 1, Ivy X Chen # 2, Jessica M Posada 2 4, Amitabh Srivastava 4, Juanye Zhang 1, Yi Zheng 5, Matthias Pinter 2 6, Sampurna Chatterjee 2, Samir Softic 7 8 9, C Ronald Kahn 7, Klaus van Leyen 5, Oliver T Bruns 1 10, Rakesh K Jain 11, Moungi G Bawendi 12
Abstract:
...Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity. We also show that the near-infrared and shortwave-infrared fluorescence of lipofuscin can be used to monitor the progression and regression of liver necroinflammation and fibrosis in mouse models of non-alcoholic fatty liver disease and advanced fibrosis, as well as to detect non-alcoholic steatohepatitis and cirrhosis in biopsied samples of human liver tissue.
PMID: 32572196
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310386/
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