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Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role
Fabio A Zucca 1, Andrea Capucciati 2, Chiara Bellei 1, Michał Sarna 3, Tadeusz Sarna 3, Enrico Monzani 2, Luigi Casella 2, Luigi Zecca 1
Abstract:
...Neuromelanins can participate in neuroprotective or toxic processes occurring in Parkinson's disease according to cellular environment...Extraneuronal neuromelanin released by dying dopamine neurons in Parkinson's disease activates microglia which generate reactive oxygen species, reactive nitrogen species, and proinflammatory molecules, thus producing still neuroinflammation and neuronal death...
PMID: 35689524
Free Full-Text: https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.2654
