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MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan
Mingfu Tian 1, Yuqing Huang 1, Yunting Song 1, Wen Li 1, Peiyi Zhao 1, Weiyong Liu 1, Kailang Wu 1, Jianguo Wu 1 2
Abstract:
...Here, it is shown that MYSM1 is a key suppressor of aging and aging-related pathologies. MYSM1 functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs. MYSM1 mechanistically attenuates the aging process by promoting DNA repair processes. Remarkably, MYSM1 deficiency facilitates the aging process and reduces lifespan, whereas MYSM1 over-expression attenuates the aging process and increases lifespan in mice. The functional role of MYSM1 is demonstrated in suppressing the aging process and prolonging lifespan. MYSM1 is a key suppressor of aging and may act as a potential agent for the prevention of aging and aging-associated diseases.
PMID: 33240758
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675055/
