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Modelling the dynamics of senescence spread
Aging Cell. 2023 Jun 8;e13892. doi: 10.1111/acel.13892.
Lucy Martin 1, Linus Schumacher 2, Tamir Chandra 1
Abstract:
...Although senescent cells are important in ageing, wound healing and cancer, it is unclear how the spread of senescence is contained in senescent lesions. In the absence of the immune system, senescence could theoretically spread infinitely from one cell to another, but this contradicts experimental evidence. To investigate this issue, we developed both a minimal mathematical model and a stochastic simulation of senescence spread. Our results suggest that differences in the number of signalling molecules secreted between subtypes of senescent cells can limit the spread of senescence. We found that dynamic, time-dependent paracrine signalling prevents the uncontrolled spread of senescence, and we demonstrate how model parameters can be determined using Bayesian inference in a proposed experiment.
PMID: 37288475
Free Full-Text: https://onlinelibrary.wiley.com/doi/10.1111/acel.13892