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Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice.
Front Pharmacol. 2019 Apr 17;10:355. doi: 10.3389/fphar.2019.00355
Olena Lykhmus, Lyudmyla Koval, Larysa Voytenko, Kateryna Uspenska, Serhiy Komisarenko, Olena Deryabina, Nadia Shuvalova, Vitalii Kordium, Alina Ustymenko, Vitalii Kyryk, Maryna Skok
Abstract:
...In the present study, we aimed to investigate whether pathogenic effect of LPS on the brain and behavior of mice can be prevented or treated by injection of MSCs or MSC-produced soluble factors. Fluorescently-labeled MSCs, injected intravenously, were found in the brain blood vessels of LPS-treated mice. Mice co-injected with LPS and MSCs did not demonstrate episodic memory impairment, Aβ (1-42) accumulation, and nAChR decrease in the brain and brain mitochondria. Their mitochondria released less cytochrome c under the effect of Ca2+ compared to mitochondria of LPS-only-treated mice. Moreover, MSCs could reverse the pathogenic symptoms developed 3 weeks after LPS injection. Cultured MSCs produced IL-6 in response to LPS and MSCs effect in vivo was accompanied by additional stimulation of both micro- and macroglia. Xenogeneic (human) MSCs were almost as efficient as allogeneic (mouse) ones and regular injections of human MSC-conditioned medium also produced positive effect. These data allow suggesting MSCs as a potential therapeutic tool to cure neuroinflammation-related cognitive pathology.
PMID: 31057400
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479176/