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Inhibition and disintegration of insulin amyloid fibrils: a facile supramolecular strategy with p-sulfonatocalixarenes.
Shinde MN, Barooah N, Bhasikuttan AC, Mohanty J
Abstract:
We reveal the ability of p-sulfonatocalix[4/6]arene to effectively inhibit the fibril formation in human insulin and demonstrate its potential to disintegrate the mature fibrils, a promising supramolecular strategy to combat amyloidosis.
