SENS PubMed Publication Search
Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways
Donald L Elbert 1, Bruce W Patterson 2, Brendan P Lucey 3 4, Tammie L S Benzinger 4 5, Randall J Bateman 3 4
Abstract:
...Here we show that changes in blood-brain barrier transport and/or proteolysis were largely responsible for the age-related decline in Aβ turnover rates. CSF-based clearance declined modestly in normal aging but became increasingly important due to the slowing of other processes. The magnitude of CSF-based clearance was also lower than that due to blood-brain barrier function plus proteolysis. These results suggest important roles for blood-brain barrier transport and proteolytic degradation of Aβ in the development Alzheimer's Disease in humans.
PMID: 35087179
Free Full-Text: https://www.nature.com/articles/s42003-022-03037-0
