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Dual enzyme responsive mannose-6-phosphate based vesicle for controlled lysosomal delivery
Basudeb Mondal 1, Tahiti Dutta, Sayam Sen Gupta
Abstract:
Dual enzyme responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. The release of the cargo from the vesicles can be temporally controlled due to the enzyme responsive morphology change of the M6P lipid assembly.
PMID: 33290458
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