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Detecting senescence: methods and approaches.
Crowe EP, Nacarelli T, Bitto A, Lerner C, Sell C, Torres C
Abstract:
.....Due to the complexity of the senescence program and the lack of a unique signature for senescence, the detection of these cells remains problematic. This is especially true for in vivo detection in aged or diseased tissue samples. This chapter outlines approaches for the detection of senescent cells based upon methods established for mesenchymal cells in culture. A stepwise approach to the detection of senescent cells using multiple techniques is provided.
PMID: 24906328
SENS Approach:
