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Delivery of cell membrane impermeable peptides into living cells by using head-to-tail cyclized mitochondria-penetrating peptides
Qian-Qian Yang 1, Liang-Jing Zhu 1, Tong-Kuai Xi 1, Han-Ying Zhu 1, Xiao-Xu Chen 1, Meng Wu 1, Chuan Sun 1, Changzhi Xu 1, Ge-Min Fang 1, Xiangming Meng 1
Abstract:
A series of cyclic Arg-rich mitochondria-penetrating peptides were prepared with variation in the macrocycle size and the chirality of Arg residues. A cyclic heptapeptide was demonstrated to be an efficient mitochondria-specific delivery vector for delivering membrane impermeable peptides.
