Theses reviewed in this issue include "Engineering Protein Disaggregases to Counter Alpha-Synuclein and Amyloid-Beta Neurotoxicity", "Hyperglycaemia induced immunomodulation of macrophages in diabetic vascular disease", "Microvasculature-on-a-Chip Systems for Human Disease Modeling", "Senescence surveillance : the interplay between the immune system and senescent cells", "The HMG Transcription Factor TOX Induces a Transcriptional and Epigenetic Program of CD8+ T Cell Exhaustion in Chronic Infection and Cancer", and "Zero to One - Translational Advancements in the Field of Xenotransplantation".