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Cellular senescence: when growth stimulation meets cell cycle arrest
Mikhail V Blagosklonny 1
Abstract:
At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell culture, the arrested cell is acquiring a senescent phenotype. What is happening during this geroconversion? Cellular enlargement (hypertrophy) and hyperfunctions (lysosomal and hyper-secretory) are hallmarks of geroconversion.
PMID: 36805938
Free Full-Text: https://www.aging-us.com/article/204543/text
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