SENS PubMed Publication Search
Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy.
Pan X, Ahmed N, Kong J, Zhang D
Abstract:
We recently reported that depletion of FANCM in ALT cells induces replication stress mainly at their telomeres. Additionally, we found that co-depletion of FANCM and BLM, or FANCM and BRCA1 induces synthetic lethality in the ALT cells. Our new findings could have important implications for cancer prevention and treatment.
PMID: 29209649
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706943/
SENS Approach:
