SENS PubMed Publication Search
Assembly of telomeric chromatin to create ALTernative endings.
O’Sullivan RJ, Almouzni G
Abstract:
.....Although it remains to be clarified why a cell chooses the ALT pathway and how ALT is initiated, recently identified mutations in factors that shape the chromatin and epigenetic landscape of ALT telomeres are shedding light on these mechanisms. In this review, we examine these recent findings and integrate them into the current models of the ALT mechanism.
PMID: 25172551
SENS Approach:
