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Alzheimer's disease neuropathological change three decades after iatrogenic amyloid-β transmission
Zane Jaunmuktane 1 2, Gargi Banerjee 3, Simon Paine 4, Adrian Parry-Jones 5 6, Peter Rudge 3 7, Joan Grieve 8, Ahmed K Toma 8, Simon F Farmer 9 10, Simon Mead 3 7, Henry Houlden 11 12, David J Werring 10 12 13, Sebastian Brandner 14 15
Abstract:
(Excerpt)
Human (iatrogenic) transmission of amyloid-β (Aβ) pathology has been shown in brain biopsy or autopsy tissues in patients with and without iatrogenic Creutzfeldt–Jakob disease (iCJD) [1, 5,6,7,8,9,10,11,12,13,14,15,16,17,18, 20,21,22] and these Aβ seeds have been detected in the archival vials containing human cadaver-derived growth hormone (hcGH) [7, 19]. Whilst tau seeds were also found in these hcGH vials [7, 19], to date, no substantial tau pathology has been observed in patients with iCJD, iatrogenically transmitted Aβ pathology or both. Here we show that a significant tau pathology, similar to that seen in patients with Alzheimer’s disease, can develop in patients with iatrogenic Aβ pathology after incubation periods exceeding 3 decades.
Human (iatrogenic) transmission of amyloid-β (Aβ) pathology has been shown in brain biopsy or autopsy tissues in patients with and without iatrogenic Creutzfeldt–Jakob disease (iCJD) [1, 5,6,7,8,9,10,11,12,13,14,15,16,17,18, 20,21,22] and these Aβ seeds have been detected in the archival vials containing human cadaver-derived growth hormone (hcGH) [7, 19]. Whilst tau seeds were also found in these hcGH vials [7, 19], to date, no substantial tau pathology has been observed in patients with iCJD, iatrogenically transmitted Aβ pathology or both. Here we show that a significant tau pathology, similar to that seen in patients with Alzheimer’s disease, can develop in patients with iatrogenic Aβ pathology after incubation periods exceeding 3 decades.
PMID: 34047818
Free Full-Text: https://link.springer.com/article/10.1007%2Fs00401-021-02326-y
