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Aggregation and fusion of low-density lipoproteins in vivo and in vitro.
Lu M, Gursky O
Abstract:
......Here, we summarize current knowledge of the in vivo and in vitro modifications of LDLs leading to their aggregation, fusion, and lipid droplet formation; outline the techniques used to study these reactions; and propose a molecular mechanism that underlies these pro-atherogenic processes. Such knowledge is essential in identifying endogenous and exogenous factors that can promote or prevent LDL aggregation and fusion in vivo and to help establish new potential therapeutic targets to decelerate or even block these pathogenic reactions.
PMID: 25197325
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154560/
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