.....This review summarizes the most recent advances concerning AGEs effects in the cavernous tissue of the penis and in erectile dysfunction onset, particularly on diabetes and aging, conditions that not only favor AGEs formation, but also increase risk of developing erectile dysfunction. The specific contribution of AGE on intra and extracellular deposition of insoluble complexes, interference in activity of endothelial nitric oxide (NO) synthase, NO bioavailability, endothelial-dependent vasodilatation, as well as molecular pathways activated by receptor of AGEs are presented. Finally, the interventional actions that prevent AGEs formation, accumulation or activity in the cavernous tissue, that include nutritional pattern modulation, nutraceuticals, exercise, therapeutic strategies (statins, anti-diabetics, inhibitors of phosphodiesterase-5, anti-hipertensive drugs) and inhibitors of AGEs formation and crosslink breakers, are discussed. From this review we conclude that despite the experiments conducted in animal models point the AGE-RAGE axis as a potential interventional target with respect to erectile dysfunction associated with diabetes and aging, the clinical data have been very disappointing and until now, did not provide evidence of benefits of treatments directed to AGEs inactivation.