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Accumulation of cellular prion protein within β-amyloid oligomer plaques in aged human brains
Reisuke H Takahashi 1 2, Mayumi Yokotsuka 1, Minoru Tobiume 2, Yuko Sato 2, Hideki Hasegawa 2, Toshitaka Nagao 1, Gunnar K Gouras 3
Abstract:
...We immunohistochemically investigated the relationship between Aβ oligomers and PrPC in human brain tissue with and without amyloid pathology. We histologically demonstrate that PrPC accumulates with aging in human brain tissue even prior to AD mainly within diffuse-type amyloid plaques, which are composed of more soluble Aβ oligomers without stacked β-sheet fibril structures. Our results suggest that PrPC accumulating plaques are associated with more soluble Aβ oligomers, and appear even prior to AD. The investigation of PrPC accumulating plaques may provide new insights into AD.
PMID: 33624334
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412093/
