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A review of therapeutic prospects of non-viral gene therapy in the retinal pigment epithelium.
Biomaterials. 2013 Sep;34(29):7158-67. doi: 10.1016/j.biomaterials.2013.06.002
Koirala A, Conley SM, Naash MI
Abstract:
.....Recent advancements in the field have yielded non-viral vectors that have favorable safety profiles, lack immunogenicity, exhibit long-term elevated gene expression, and show efficient transfection in the retina and RPE, making them poised to transition to clinical applications. Here we discuss the advancements in nanotechnology and vector engineering that have improved the prospects for clinical application of non-viral gene therapy in the RPE.
PMID: 23796578
Tags: AMD, gene therapy