SENS PubMed Publication Search
Landscape of somatic mutations in aging human heart muscle cells
Nat Aging. 2022 Aug;2(8):686-687. doi: 10.1038/s43587-022-00264-2.
Christopher Walsh 1, Sangita Choudhury 1, Ming Hui Chen 1
Abstract:
Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.
PMID: 36471785
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719721/
Tags: heart, humans, Post-mitotic cells, somatic mutations