...Herein, a therapeutic nanosweeper (NS) with Aβ removal capability is developed. NS can be efficiently loaded into neutrophils (NE) to form NS/NE to improve its BBB crossing efficiency and preserve its Aβ removal capability after being released from neutrophils. With this capability, NS can be efficiently delivered into the brain in the form of NS/NE owing to its chemotaxis to inflammatory factors released from AD brain. Moreover, NS released from NS/NE preserved its Aβ removal capability, thereby significantly alleviating the pathological symptoms of Aβ deposition and neuronal apoptosis in AD mice.