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Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres
Taylor K Loe 1, Julia Su Zhou Li 2, Yuxiang Zhang 1, Benura Azeroglu 3, Michael Nicholas Boddy 1, Eros Lazzerini Denchi 3
Abstract:
...Here, we used CRISPR/Cas9 to delete PML and APB components from ALT-positive cells to cleanly define the function of APBs in ALT. We found that PML is required for the ALT mechanism, and that this necessity stems from APBs' role in localizing the BLM-TOP3A-RMI (BTR) complex to ALT telomere ends. Strikingly, recruitment of the BTR complex to telomeres in a PML-independent manner bypasses the need for PML in the ALT pathway, suggesting that BTR localization to telomeres is sufficient to sustain ALT activity.
PMID: 32217664
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197349/
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