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Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum
Luca Camparini 1, Laxmikanth Kollipara 2, Gianfranco Sinagra 3, Francesco S Loffredo 1 4, Albert Sickmann 2, Olga Shevchuk 2
Abstract:
...Here a novel detection method is demonstrated based on parallel reaction monitoring LC-MS/MS assay combined with immunoprecipitation to reliably distinguish GDF11 and GDF8 as well as determine their endogenous levels in mouse serum. The data indicate that both GDF11 and GDF8 circulating levels significantly decline with aging in female mice.
PMID: 32104967
Free Full-Text: https://onlinelibrary.wiley.com/doi/10.1002/pmic.201900104
