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How does the body know how old it is? Introducing the epigenetic clock hypothesis.
Mitteldorf J
Abstract:
.....Gene expression is known to change in characteristic ways with age, and in particular DNA methylation changes in age-related ways. Herein, I propose a new candidate for an aging clock, based on epigenetics and the state of chromosome methylation, particularly in stem cells. If validated, this mechanism would present a challenging but not impossible target for medical intervention.
