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Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.
Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL
Abstract:
.....We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice.
Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis
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Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis
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