.....We previously reported on positive immune remodeling in humans taking a commercial health maintenance program, PattonProtocol-1, composed of TA-65® (a natural product-derived telomerase activator) and other dietary supplements (1). In over a 5 year period and an estimated 7000 person-years of use, no adverse events or effects have been attributed to TA-65 by physicians licensed to sell the product. Here we report on changes in metabolic markers measured at baseline (n=97-107 subjects) and every 3-6 months (n=27-59 subjects) during the first 12 months of study. Rates of change per year from baseline determined by mixed effects ANOVA were -3.72 mg/dL for fasting glucose (p=.02), -1.32 mIU/mL for insulin (p=0.01), -13.2 and -11.8 mg/dL for total- and LDL-cholesterol (p=0.002, p=0.002, respectively), -17.3 and -4.2 mm Hg for systolic and diastolic blood pressure (p=0.007 and 0.001, respectively), and -3.6 umole/L homocysteine (p=0.001). In a subset of individuals with bone mineral density (BMD) measured at baseline and 12 months, density increased 2.0% in the spine (p=0.003). We conclude that in addition to apparent positive immune remodeling, PattonProtocol-1 may improve markers of metabolic, bone and cardiovascular health.