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Clinical Application of Adult Stem Cells for Therapy of Cardiac Disease.
Ghodsizad A, Ruhparwar A, Bordel V, Mirsaidighazi E, Klein HM, Koerner MM, Karck M, El-Banayosy A
Abstract:
INTRODUCTION:
.....Here we are giving a comprehensive overview on major available clinical data regarding cell therapy.
BACKGROUND:
Cell-based therapies and tissue engineering provide new promising platforms to develop upcoming therapeutic options. Initial clinical trials were able to generate promising results. A variety of different stem cell types, have been used for the clinical application. Different adult cardiac stem cells and progenitor cells, including mesenchymal, CD34+ and CD133+ autologous human bone marrow derived stem cells (BMCs), human myoblasts, peripherial blood derived stem and progenitor cells (PBSC) have been used for the therapy of endstage heart failure. Future experiments will show the importance of novel cell populations and clarify the mechanism causing cell therapy mediated observed effects.
CONCLUSION:
Several clinical trials have reported on sole therapy, as well as combined application of autologous adult stem cells with conventional revascularization.....
.....Here we are giving a comprehensive overview on major available clinical data regarding cell therapy.
BACKGROUND:
Cell-based therapies and tissue engineering provide new promising platforms to develop upcoming therapeutic options. Initial clinical trials were able to generate promising results. A variety of different stem cell types, have been used for the clinical application. Different adult cardiac stem cells and progenitor cells, including mesenchymal, CD34+ and CD133+ autologous human bone marrow derived stem cells (BMCs), human myoblasts, peripherial blood derived stem and progenitor cells (PBSC) have been used for the therapy of endstage heart failure. Future experiments will show the importance of novel cell populations and clarify the mechanism causing cell therapy mediated observed effects.
CONCLUSION:
Several clinical trials have reported on sole therapy, as well as combined application of autologous adult stem cells with conventional revascularization.....
